Fundamental role for HIF-1α in constitutive expression of human β defensin-1

Antimicrobial peptides are secreted by the intestinal epithelium to defend from microbial threats. The role of human β defensin-1 (hBD-1) is notable because its gene (beta-defensin 1 (DEFB1)) is constitutively expressed and its antimicrobial activity is potentiated in the low-oxygen environment that...

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Autores principales: Kelly, C J, Glover, L E, Campbell, E L, Kominsky, D J, Ehrentraut, S F, Bowers, B E, Bayless, A J, Saeedi, B J, Colgan, S P
Formato: Artigo
Lenguaje:Inglês
Publicado: Nature Publishing Group 2013
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3740147/
https://ncbi.nlm.nih.gov/pubmed/23462909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/mi.2013.6
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