Pre-steady-state kinetics shows differences in processing of various DNA lesions by Escherichia coli formamidopyrimidine-DNA glycosylase

Formamidopyrimidine-DNA-glycosylase (Fpg pro tein, MutM) catalyses excision of 8-oxoguanine (8-oxoG) and other oxidatively damaged purines from DNA in a glycosylase/apurinic/apyrimidinic-lyase reaction. We report pre-steady-state kinetic analysis of Fpg action on oligonucleotide duplexes containing...

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Main Authors: Koval, Vladimir V., Kuznetsov, Nikita A., Zharkov, Dmitry O., Ishchenko, Alexander A., Douglas, Kenneth T., Nevinsky, Georgy A., Fedorova, Olga S.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2004
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Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC373384/
https://ncbi.nlm.nih.gov/pubmed/14769949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkh237
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