FOXOs attenuate bone formation by suppressing Wnt signaling

Wnt/β-catenin/TCF signaling stimulates bone formation and suppresses adipogenesis. The hallmarks of skeletal involution with age, on the other hand, are decreased bone formation and increased bone marrow adiposity. These changes are associated with increased oxidative stress and decreased growth fac...

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Détails bibliographiques
Auteurs principaux: Iyer, Srividhya, Ambrogini, Elena, Bartell, Shoshana M., Han, Li, Roberson, Paula K., de Cabo, Rafael, Jilka, Robert L., Weinstein, Robert S., O’Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2013
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726166/
https://ncbi.nlm.nih.gov/pubmed/23867625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68049
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