FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H(2)O(2) accumulation

Besides their cell-damaging effects in the setting of oxidative stress, reactive oxygen species (ROS) play an important role in physiological intracellular signalling by triggering proliferation and survival. FoxO transcription factors counteract ROS generation by upregulating antioxidant enzymes. H...

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Detalhes bibliográficos
Main Authors: Bartell, Shoshana M., Kim, Ha-Neui, Ambrogini, Elena, Han, Li, Iyer, Srividhya, Serra Ucer, S., Rabinovitch, Peter, Jilka, Robert L., Weinstein, Robert S., Zhao, Haibo, O’Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015330/
https://ncbi.nlm.nih.gov/pubmed/24781012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4773
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