FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H(2)O(2) accumulation

Besides their cell-damaging effects in the setting of oxidative stress, reactive oxygen species (ROS) play an important role in physiological intracellular signalling by triggering proliferation and survival. FoxO transcription factors counteract ROS generation by upregulating antioxidant enzymes. H...

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Autori principali: Bartell, Shoshana M., Kim, Ha-Neui, Ambrogini, Elena, Han, Li, Iyer, Srividhya, Serra Ucer, S., Rabinovitch, Peter, Jilka, Robert L., Weinstein, Robert S., Zhao, Haibo, O’Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Pub. Group 2014
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015330/
https://ncbi.nlm.nih.gov/pubmed/24781012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4773
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