FoxO proteins restrain osteoclastogenesis and bone resorption by attenuating H(2)O(2) accumulation

Besides their cell-damaging effects in the setting of oxidative stress, reactive oxygen species (ROS) play an important role in physiological intracellular signalling by triggering proliferation and survival. FoxO transcription factors counteract ROS generation by upregulating antioxidant enzymes. H...

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Main Authors: Bartell, Shoshana M., Kim, Ha-Neui, Ambrogini, Elena, Han, Li, Iyer, Srividhya, Serra Ucer, S., Rabinovitch, Peter, Jilka, Robert L., Weinstein, Robert S., Zhao, Haibo, O’Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Format: Artigo
Sprog:Inglês
Udgivet: Nature Pub. Group 2014
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4015330/
https://ncbi.nlm.nih.gov/pubmed/24781012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms4773
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