Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs

Activation of Sirtuin1 (Sirt1), an nicotinamide adenine dinucleotide oxidized-dependent deacetylase, by natural or synthetic compounds like resveratrol, SRT2104, or SRT3025 attenuates the loss of bone mass caused by ovariectomy, aging, or unloading in mice. Conversely, Sirt1 deletion in osteoclast p...

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Publicado en:Mol Endocrinol
Autores principales: Kim, Ha-Neui, Han, Li, Iyer, Srividhya, de Cabo, Rafael, Zhao, Haibo, O'Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Formato: Artigo
Lenguaje:Inglês
Publicado: Endocrine Society 2015
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Original Research
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588729/
https://ncbi.nlm.nih.gov/pubmed/26287518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1133
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