Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs

Activation of Sirtuin1 (Sirt1), an nicotinamide adenine dinucleotide oxidized-dependent deacetylase, by natural or synthetic compounds like resveratrol, SRT2104, or SRT3025 attenuates the loss of bone mass caused by ovariectomy, aging, or unloading in mice. Conversely, Sirt1 deletion in osteoclast p...

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Bibliografiske detaljer
Udgivet i:Mol Endocrinol
Main Authors: Kim, Ha-Neui, Han, Li, Iyer, Srividhya, de Cabo, Rafael, Zhao, Haibo, O'Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Format: Artigo
Sprog:Inglês
Udgivet: Endocrine Society 2015
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588729/
https://ncbi.nlm.nih.gov/pubmed/26287518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1133
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