Sirtuin1 Suppresses Osteoclastogenesis by Deacetylating FoxOs

Activation of Sirtuin1 (Sirt1), an nicotinamide adenine dinucleotide oxidized-dependent deacetylase, by natural or synthetic compounds like resveratrol, SRT2104, or SRT3025 attenuates the loss of bone mass caused by ovariectomy, aging, or unloading in mice. Conversely, Sirt1 deletion in osteoclast p...

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Publicat a:Mol Endocrinol
Autors principals: Kim, Ha-Neui, Han, Li, Iyer, Srividhya, de Cabo, Rafael, Zhao, Haibo, O'Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Format: Artigo
Idioma:Inglês
Publicat: Endocrine Society 2015
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4588729/
https://ncbi.nlm.nih.gov/pubmed/26287518
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/me.2015-1133
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