FOXOs attenuate bone formation by suppressing Wnt signaling

Wnt/β-catenin/TCF signaling stimulates bone formation and suppresses adipogenesis. The hallmarks of skeletal involution with age, on the other hand, are decreased bone formation and increased bone marrow adiposity. These changes are associated with increased oxidative stress and decreased growth fac...

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Bibliografische gegevens
Hoofdauteurs: Iyer, Srividhya, Ambrogini, Elena, Bartell, Shoshana M., Han, Li, Roberson, Paula K., de Cabo, Rafael, Jilka, Robert L., Weinstein, Robert S., O’Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: American Society for Clinical Investigation 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726166/
https://ncbi.nlm.nih.gov/pubmed/23867625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68049
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