FOXOs attenuate bone formation by suppressing Wnt signaling

Wnt/β-catenin/TCF signaling stimulates bone formation and suppresses adipogenesis. The hallmarks of skeletal involution with age, on the other hand, are decreased bone formation and increased bone marrow adiposity. These changes are associated with increased oxidative stress and decreased growth fac...

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Detalhes bibliográficos
Main Authors: Iyer, Srividhya, Ambrogini, Elena, Bartell, Shoshana M., Han, Li, Roberson, Paula K., de Cabo, Rafael, Jilka, Robert L., Weinstein, Robert S., O’Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726166/
https://ncbi.nlm.nih.gov/pubmed/23867625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68049
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