FOXOs attenuate bone formation by suppressing Wnt signaling

Wnt/β-catenin/TCF signaling stimulates bone formation and suppresses adipogenesis. The hallmarks of skeletal involution with age, on the other hand, are decreased bone formation and increased bone marrow adiposity. These changes are associated with increased oxidative stress and decreased growth fac...

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Main Authors: Iyer, Srividhya, Ambrogini, Elena, Bartell, Shoshana M., Han, Li, Roberson, Paula K., de Cabo, Rafael, Jilka, Robert L., Weinstein, Robert S., O’Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Format: Artigo
Jezik:Inglês
Izdano: American Society for Clinical Investigation 2013
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Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726166/
https://ncbi.nlm.nih.gov/pubmed/23867625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68049
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