FOXOs attenuate bone formation by suppressing Wnt signaling

Wnt/β-catenin/TCF signaling stimulates bone formation and suppresses adipogenesis. The hallmarks of skeletal involution with age, on the other hand, are decreased bone formation and increased bone marrow adiposity. These changes are associated with increased oxidative stress and decreased growth fac...

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Autori principali: Iyer, Srividhya, Ambrogini, Elena, Bartell, Shoshana M., Han, Li, Roberson, Paula K., de Cabo, Rafael, Jilka, Robert L., Weinstein, Robert S., O’Brien, Charles A., Manolagas, Stavros C., Almeida, Maria
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2013
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3726166/
https://ncbi.nlm.nih.gov/pubmed/23867625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI68049
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