Sandmeyer reaction repurposed for the site-selective, non-oxidizing radioiodination of fully-deprotected peptides: Studies on the endogenous opioid peptide α-neoendorphin

Standard radioiodination methods lack site-selectivity and either mask charges (Bolton-Hunter) or involve oxidative reaction conditions (chloramine-T). Opioid peptides are very sensitive to certain structural modifications, making these labeling methods untenable. In our model opioid peptide, α-neoe...

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Detalhes bibliográficos
Main Authors: Pickett, Julie E., Nagakura, Kunihiko, Pasternak, Anna R., Grinnell, Steven G., Majumdar, Susruta, Lewis, Jason S., Pasternak, Gavril W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3725135/
https://ncbi.nlm.nih.gov/pubmed/23796454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmcl.2013.05.090
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