Ferritin light chain interacts with PEN-2 and affects γ-secretase activity

Alzheimer’s disease (AD) is primarily caused by overproduction/deposition of β-amyloid (Aβ) in the brain. Dysregulation of iron in the brain also contributes to AD. Although iron affects β-amyloid precursor protein (APP) expression and Aβ deposition, detailed role of iron in AD requires further eluc...

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Autori principali: Li, Xinxin, Liu, Yiqian, Zheng, Qiuyang, Yao, Guorui, Cheng, Peng, Bu, Guojun, Xu, Huaxi, Zhang, Yun-wu
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2013
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724929/
https://ncbi.nlm.nih.gov/pubmed/23685131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neulet.2013.05.018
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