Suppression of Cytochrome P450 Reductase Enhances Long-Term Hematopoietic Stem Cell Repopulation Efficiency in Mice

BACKGROUND: Bone marrow microenvironment (niche) plays essential roles in the fate of hematopoietic stem cells (HSCs). Intracellular and extracellular redox metabolic microenvironment is one of the critical factors for the maintenance of the niche. Cytochrome P450 reductase (CPR) is an obligate elec...

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Hoofdauteurs: Zhang, Yan, Dong, Fang, Zhang, Na, Cheng, Hui, Pang, Yakun, Wang, Xiaomin, Xu, Jing, Ding, Xinxin, Cheng, Tao, Gu, Jun, Yuan, Weiping
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Public Library of Science 2013
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Research Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724780/
https://ncbi.nlm.nih.gov/pubmed/23922855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069913
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