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Suppression of Cytochrome P450 Reductase Enhances Long-Term Hematopoietic Stem Cell Repopulation Efficiency in Mice

BACKGROUND: Bone marrow microenvironment (niche) plays essential roles in the fate of hematopoietic stem cells (HSCs). Intracellular and extracellular redox metabolic microenvironment is one of the critical factors for the maintenance of the niche. Cytochrome P450 reductase (CPR) is an obligate elec...

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Bibliografiske detaljer
Main Authors: Zhang, Yan, Dong, Fang, Zhang, Na, Cheng, Hui, Pang, Yakun, Wang, Xiaomin, Xu, Jing, Ding, Xinxin, Cheng, Tao, Gu, Jun, Yuan, Weiping
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724780/
https://ncbi.nlm.nih.gov/pubmed/23922855
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069913
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