Generation of a Mouse Model with a Reversible Hypomorphic Cytochrome P450 Reductase Gene: Utility for Tissue-Specific Rescue of the Reductase Expression, and Insights from a Resultant Mouse Model with Global Suppression of P450 Reductase Expression in Extrahepatic Tissues

A mouse model termed Cpr-low (CL) was recently generated, in which the expression of the cytochrome P450 reductase (Cpr) gene was globally down-regulated. The decreased CPR expression was accompanied by phenotypical changes, including reduced embryonic survival, decreases in circulating cholesterol,...

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Bibliographische Detailangaben
Hauptverfasser: Wei, Yuan, Zhou, Xin, Fang, Cheng, Li, Lei, Kluetzman, Kerri, Yang, Weizhu, Zhang, Qing-Yu, Ding, Xinxin
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2010
Schlagworte:
Toxicology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2912046/
https://ncbi.nlm.nih.gov/pubmed/20375200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.167411
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