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tBid Undergoes Multiple Conformational Changes at the Membrane Required for Bax Activation
Bid is a Bcl-2 family protein that promotes apoptosis by activating Bax and eliciting mitochondrial outer membrane permeabilization (MOMP). Full-length Bid is cleaved in response to apoptotic stimuli into two fragments, p7 and tBid (p15), that are held together by strong hydrophobic interactions unt...
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| Hauptverfasser: | , , , , , , , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
American Society for Biochemistry and Molecular Biology
2013
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3724664/ https://ncbi.nlm.nih.gov/pubmed/23744079 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.482109 |
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