Multiple partners can kiss-and-run: Bax transfers between multiple membranes and permeabilizes those primed by tBid

During apoptosis Bid and Bax are sufficient for mitochondrial outer membrane permeabilization, releasing pro-apoptotic proteins such as cytochrome c and Smac/Diablo into the cytoplasm. In most cells, both Bid and Bax are cytoplasmic but bind to mitochondrial outer membranes to exert pro-apoptotic fu...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Shamas-Din, A, Satsoura, D, Khan, O, Zhu, W, Leber, B, Fradin, C, Andrews, D W
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2014
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4611711/
https://ncbi.nlm.nih.gov/pubmed/24901048
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddis.2014.234
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