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Phosphatidic acid mediates the targeting of tBid to induce lysosomal membrane permeabilization and apoptosis
Upon apoptotic stimuli, lysosomal proteases, including cathepsins and chymotrypsin, are released into cytosol due to lysosomal membrane permeabilization (LMP), where they trigger apoptosis via the lysosomal-mitochondrial pathway of apoptosis. Herein, the mechanism of LMP was investigated. We found t...
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| Main Authors: | , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The American Society for Biochemistry and Molecular Biology
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3435543/ https://ncbi.nlm.nih.gov/pubmed/22761256 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M027557 |
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