tBID ELICITS A CONFORMATIONAL ALTERATION IN MEMBRANE-BOUND BCL-2 SUCH THAT IT INHIBITS BAX PORE FORMATION

During initiation of apoptosis, Bcl-2 family proteins regulate the permeability of mitochondrial outer membrane. BH3-only protein, tBid, activates pro-apoptotic Bax to release cytochrome c from mitochondria. tBid also activates anti-apoptotic Bcl-2 in the mitochondrial outer membrane, changing it fr...

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Detalhes bibliográficos
Main Authors: Peng, Jun, Tan, Chibing, Roberts, G. Jane, Nikolaeva, Olga, Zhang, Zhi, Lapolla, Suzanne M., Primorac, Steve, Andrews, David W., Lin, Jialing
Formato: Artigo
Idioma:Inglês
Publicado em: 2006
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2825177/
https://ncbi.nlm.nih.gov/pubmed/17005564
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M608303200
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