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tBID ELICITS A CONFORMATIONAL ALTERATION IN MEMBRANE-BOUND BCL-2 SUCH THAT IT INHIBITS BAX PORE FORMATION
During initiation of apoptosis, Bcl-2 family proteins regulate the permeability of mitochondrial outer membrane. BH3-only protein, tBid, activates pro-apoptotic Bax to release cytochrome c from mitochondria. tBid also activates anti-apoptotic Bcl-2 in the mitochondrial outer membrane, changing it fr...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2006
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2825177/ https://ncbi.nlm.nih.gov/pubmed/17005564 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M608303200 |
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