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Oligomerization of membrane-bound Bcl-2 is involved in its pore formation induced by tBid
Both proapoptotic Bax and antiapoptotic Bcl-2 are structurally homologous to the pore-forming domain of bacterial toxins. Bax proteins oligomerize in the mitochondrial outer membranes forming pores that release cytochrome c from the mitochondrial intermembrane space. Bcl-2 proteins also form pores t...
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| Main Authors: | , , , , , , |
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| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
2009
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858642/ https://ncbi.nlm.nih.gov/pubmed/19701793 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10495-009-0389-8 |
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