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The Cytosolic Domain of Bcl-2 Forms Small Pores on Model Mitochondrial Outer Membrane After Acidic pH-Induced Membrane Association

The permeability of mitochondrial outer membrane (MOM) is regulated by proteins of the Bcl-2 family via their interactions at the membrane. While pro-apoptotic Bax protein promotes MOM permeabilization (MOMP) releasing cytochrome c after activation by BH3-only protein, anti-apoptotic Bcl-2 protein p...

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Detalhes bibliográficos
Main Authors: Peng, Jun, Lapolla, Suzanne M., Zhang, Zhi, Lin, Jialing
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2844873/
https://ncbi.nlm.nih.gov/pubmed/19334571
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