tBid Undergoes Multiple Conformational Changes at the Membrane Required for Bax Activation

Bid is a Bcl-2 family protein that promotes apoptosis by activating Bax and eliciting mitochondrial outer membrane permeabilization (MOMP). Full-length Bid is cleaved in response to apoptotic stimuli into two fragments, p7 and tBid (p15), that are held together by strong hydrophobic interactions unt...

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Bibliographic Details
Main Authors: Shamas-Din, Aisha, Bindner, Scott, Zhu, Weijia, Zaltsman, Yehudit, Campbell, Clinton, Gross, Atan, Leber, Brian, Andrews, David W., Fradin, Cécile
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Cell Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724664/
https://ncbi.nlm.nih.gov/pubmed/23744079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.482109
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