Parkin-catalyzed Ubiquitin-Ester Transfer Is Triggered by PINK1-dependent Phosphorylation

PINK1 and PARKIN are causal genes for autosomal recessive familial Parkinsonism. PINK1 is a mitochondrial Ser/Thr kinase, whereas Parkin functions as an E3 ubiquitin ligase. Under steady-state conditions, Parkin localizes to the cytoplasm where its E3 activity is repressed. A decrease in mitochondri...

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Main Authors: Iguchi, Masahiro, Kujuro, Yuki, Okatsu, Kei, Koyano, Fumika, Kosako, Hidetaka, Kimura, Mayumi, Suzuki, Norihiro, Uchiyama, Shinichiro, Tanaka, Keiji, Matsuda, Noriyuki
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2013
Teme:
Protein Synthesis and Degradation
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724655/
https://ncbi.nlm.nih.gov/pubmed/23754282
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M113.467530
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