The Peptidyl-prolyl Isomerase Pin1 Up-regulation and Proapoptotic Function in Dopaminergic Neurons: RELEVANCE TO THE PATHOGENESIS OF PARKINSON DISEASE

Parkinson disease (PD) is a chronic neurodegenerative disease characterized by a slow and progressive degeneration of dopaminergic neurons in substantia nigra. The pathophysiological mechanisms underlying PD remain unclear. Pin1, a major peptidyl-prolyl isomerase, has recently been associated with c...

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Bibliographic Details
Main Authors: Ghosh, Anamitra, Saminathan, Hariharan, Kanthasamy, Arthi, Anantharam, Vellareddy, Jin, Huajun, Sondarva, Gautam, Harischandra, Dilshan S., Qian, Ziqing, Rana, Ajay, Kanthasamy, Anumantha G.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2013
Subjects:
Molecular Bases of Disease
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724650/
https://ncbi.nlm.nih.gov/pubmed/23754278
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.444224
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