Histone Hyperacetylation Up-regulates Protein Kinase Cδ in Dopaminergic Neurons to Induce Cell Death: RELEVANCE TO EPIGENETIC MECHANISMS OF NEURODEGENERATION IN PARKINSON DISEASE

The oxidative stress-sensitive protein kinase Cδ (PKCδ) has been implicated in dopaminergic neuronal cell death. However, little is known about the epigenetic mechanisms regulating PKCδ expression in neurons. Here, we report a novel mechanism by which the PKCδ gene can be regulated by histone acetyl...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Jin, Huajun, Kanthasamy, Arthi, Harischandra, Dilshan S., Kondru, Naveen, Ghosh, Anamitra, Panicker, Nikhil, Anantharam, Vellareddy, Rana, Ajay, Kanthasamy, Anumantha G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Gene Regulation
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4263877/
https://ncbi.nlm.nih.gov/pubmed/25342743
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.576702
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados