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Design, Synthesis, and Binding Affinity of Homologated 4′-Thioadenosine Derivatives at the human A(3) Adenosine receptor
We synthesized homologated truncated 4′-thioadenosine analogues 3 in which a methylene (CH(2)) group was inserted in place of the glycosidic bond of a potent and selective A(3) adenosine receptor antagonist 2. The analogues were designed to induce maximum binding interaction in the binding site of t...
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| Auteurs principaux: | , , , , , , , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3724522/ https://ncbi.nlm.nih.gov/pubmed/20826090 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.08.018 |
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