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Design, Synthesis, and Binding Affinity of Homologated 4′-Thioadenosine Derivatives at the human A(3) Adenosine receptor

We synthesized homologated truncated 4′-thioadenosine analogues 3 in which a methylene (CH(2)) group was inserted in place of the glycosidic bond of a potent and selective A(3) adenosine receptor antagonist 2. The analogues were designed to induce maximum binding interaction in the binding site of t...

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Bibliografiske detaljer
Main Authors: Lee, Hyuk Woo, Kim, Hea Ok, Choi, Won Jun, Choi, Sun, Lee, Jin Hee, Park, Seul-gi, Yoo, Lena, Jacobson, Kenneth A., Jeong, Lak Shin
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3724522/
https://ncbi.nlm.nih.gov/pubmed/20826090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2010.08.018
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