KMUP-1 Suppresses RANKL-Induced Osteoclastogenesis and Prevents Ovariectomy-Induced Bone Loss: Roles of MAPKs, Akt, NF-κB and Calcium/Calcineurin/NFATc1 Pathways

BACKGROUND: KMUP-1 is a xanthine derivative with inhibitory activities on the phosphodiesterase (PDE) 3,4 and 5 isoenzymes to suppress the degradation of cyclic AMP and cyclic GMP. However, the effects of KMUP-1 on osteoclast differentiation are still unclear. In this study, we investigated whether...

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Detalhes bibliográficos
Main Authors: Liou, Shu-Fen, Hsu, Jong-Hau, Lin, I-Ling, Ho, Mei-Ling, Hsu, Pei-Chuan, Chen, Li-Wen, Chen, Ing-Jun, Yeh, Jwu-Lai
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723916/
https://ncbi.nlm.nih.gov/pubmed/23936022
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0069468
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