KMUP-1 Attenuates Endothelin-1-Induced Cardiomyocyte Hypertrophy through Activation of Heme Oxygenase-1 and Suppression of the Akt/GSK-3β, Calcineurin/NFATc4 and RhoA/ROCK Pathways

The signaling cascades of the mitogen activated protein kinase (MAPK) family, calcineurin/NFATc4, and PI3K/Akt/GSK3, are believed to participate in endothelin-1 (ET-1)-induced cardiac hypertrophy. The aim of this study was to investigate whether KMUP-1, a synthetic xanthine-based derivative, prevent...

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Detalhes bibliográficos
Publicado no:Molecules
Main Authors: Liou, Shu-Fen, Hsu, Jong-Hau, Chen, You-Ting, Chen, Ing-Jun, Yeh, Jwu-Lai
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6272697/
https://ncbi.nlm.nih.gov/pubmed/26056815
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/molecules200610435
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