KMUP-1 attenuates isoprenaline-induced cardiac hypertrophy in rats through NO/cGMP/PKG and ERK1/2/calcineurin A pathways

BACKGROUND AND PURPOSE: To determine whether KMUP-1, a novel xanthine-based derivative, attenuates isoprenaline (ISO)-induced cardiac hypertrophy in rats, and if so, whether the anti-hypertrophic effect is mediated by the nitric oxide (NO) pathway. EXPERIMENTAL APPROACH: In vivo, cardiac hypertrophy...

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Autori principali: Yeh, Jwu-Lai, Hsu, Jong-Hau, Wu, Ping-Ju, Liou, Shu-Fen, Liu, Chung-Pin, Chen, Ing-Jun, Wu, Bin-Nan, Dai, Zen-Kong, Wu, Jiunn-Ren
Natura: Artigo
Lingua:Inglês
Pubblicazione: Blackwell Publishing Ltd 2010
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Research Papers
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2839273/
https://ncbi.nlm.nih.gov/pubmed/20132211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2009.00587.x
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