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“Three-in-one” chromatography-free purification, tag removal, and site-specific modification of recombinant fusion proteins using Sortase A and elastin-like polypeptides

Applied in tandem, elastin-like polypeptides (ELPs) and the sortase A (SrtA) transpeptidase from Staphylococcus aureus provide a general method for chromatography-free purification of tag-free recombinant proteins and optional, site-specific and homogeneous conjugation of the protein to a small mole...

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Bibliographische Detailangaben
Hauptverfasser: Bellucci, Joseph J., Amiram, Miriam, Bhattacharyya, Jayanta, McCafferty, Dewey, Chilkoti, Ashutosh
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723126/
https://ncbi.nlm.nih.gov/pubmed/23424160
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201208292
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