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Sortase-Catalyzed Initiator Attachment Enables High Yield Growth of a Stealth Polymer from the C Terminus of a Protein

Conventional methods for synthesizing protein/peptide–polymer conjugates, as a means to improve the pharmacological properties of therapeutic biomolecules, typically have drawbacks including low yield, non-trivial separation of conjugates from reactants, and lack of site-specificity, which results i...

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Autors principals: Qi, Yizhi, Amiram, Miriam, Gao, Weiping, McCafferty, Dewey G., Chilkoti, Ashutosh
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3754797/
https://ncbi.nlm.nih.gov/pubmed/23836349
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/marc.201300460
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