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SITE-SPECIFIC AND STOICHIOMETRIC STEALTH POLYMER CONJUGATES OF THERAPEUTIC PEPTIDES AND PROTEINS

As potent and selective therapeutic agents, peptides and proteins are an important class of drugs, but they typically have sub-optimal pharmacokinetic profiles. One approach to solve this problem is by their conjugation with “stealth” polymers. Conventional methods for conjugation of this class of p...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Veröffentlicht in:Bioconjug Chem
Hauptverfasser: Ozer, Imran, Chilkoti, Ashutosh
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2017
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6372107/
https://ncbi.nlm.nih.gov/pubmed/27998056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.bioconjchem.6b00652
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