Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation

Many proteins suffer from sub-optimal pharmacokinetics (PK) that limit their utility as drugs. The efficient synthesis of polymer conjugates of protein drugs with tunable PK to optimize their in vivo efficacy is hence critical. We report here the first study of the in vivo behavior of a site-specifi...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Chembiochem
Prif Awduron: Bhattacharjee, Somnath, Liu, Wenge, Wang, Wei-Han, Weitzhandler, Isaac, Li, Xinghai, Qi, Yizhi, Liu, Jinyao, Pang, Yan, Hunt, Donald F., Chilkoti, Ashutosh
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2015
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802966/
https://ncbi.nlm.nih.gov/pubmed/26481301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500439
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