Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation

Many proteins suffer from sub-optimal pharmacokinetics (PK) that limit their utility as drugs. The efficient synthesis of polymer conjugates of protein drugs with tunable PK to optimize their in vivo efficacy is hence critical. We report here the first study of the in vivo behavior of a site-specifi...

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Detalhes bibliográficos
Publicado no:Chembiochem
Main Authors: Bhattacharjee, Somnath, Liu, Wenge, Wang, Wei-Han, Weitzhandler, Isaac, Li, Xinghai, Qi, Yizhi, Liu, Jinyao, Pang, Yan, Hunt, Donald F., Chilkoti, Ashutosh
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802966/
https://ncbi.nlm.nih.gov/pubmed/26481301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500439
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