Site-Specific Zwitterionic Polymer Conjugates of a Protein Have Long Plasma Circulation

Many proteins suffer from sub-optimal pharmacokinetics (PK) that limit their utility as drugs. The efficient synthesis of polymer conjugates of protein drugs with tunable PK to optimize their in vivo efficacy is hence critical. We report here the first study of the in vivo behavior of a site-specifi...

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Detaylı Bibliyografya
Yayımlandı:Chembiochem
Asıl Yazarlar: Bhattacharjee, Somnath, Liu, Wenge, Wang, Wei-Han, Weitzhandler, Isaac, Li, Xinghai, Qi, Yizhi, Liu, Jinyao, Pang, Yan, Hunt, Donald F., Chilkoti, Ashutosh
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2015
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802966/
https://ncbi.nlm.nih.gov/pubmed/26481301
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cbic.201500439
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