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A non-canonical function of sortase enables site-specific conjugation of small molecules to lysine residues in proteins
We provide the first demonstration that isopeptide ligation, a non-canonical activity of the enzyme sortase A, can be used to modify recombinant proteins. This reaction was used in vitro to conjugate small molecules to a peptide, an engineered targeting protein, and a full-length monoclonal antibody...
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| Udgivet i: | Angew Chem Int Ed Engl |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4314310/ https://ncbi.nlm.nih.gov/pubmed/25363491 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201408126 |
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