In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.

The cytotoxic nucleoside 2'-deoxyadenosine is excreted in excessive amounts by individuals with genetic deficiency of adenosine deaminase, and may be in part responsible for the severe combined immune dysfunction from which they suffer. Earlier studies from this laboratory showed that 2'-deoxyadenos...

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Veröffentlicht in:	J Clin Invest
Hauptverfasser:	Hershfield, M S, Kredich, N M, Ownby, D R, Ownby, H, Buckley, R
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Clinical Investigation 1979
Schlagworte:	Research Article
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372019/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/312296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109367
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