In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.

The cytotoxic nucleoside 2'-deoxyadenosine is excreted in excessive amounts by individuals with genetic deficiency of adenosine deaminase, and may be in part responsible for the severe combined immune dysfunction from which they suffer. Earlier studies from this laboratory showed that 2'-deoxyadenos...

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Bibliografiske detaljer

Udgivet i:	J Clin Invest
Principais autores:	Hershfield, M S, Kredich, N M, Ownby, D R, Ownby, H, Buckley, R
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Clinical Investigation 1979
Fag:	Research Article
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372019/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/312296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109367
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