In vivo inactivation of erythrocyte S-adenosylhomocysteine hydrolase by 2'-deoxyadenosine in adenosine deaminase-deficient patients.

The cytotoxic nucleoside 2'-deoxyadenosine is excreted in excessive amounts by individuals with genetic deficiency of adenosine deaminase, and may be in part responsible for the severe combined immune dysfunction from which they suffer. Earlier studies from this laboratory showed that 2'-deoxyadenos...

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Detalles Bibliográficos

Publicado en:	J Clin Invest
Principais autores:	Hershfield, M S, Kredich, N M, Ownby, D R, Ownby, H, Buckley, R
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Clinical Investigation 1979
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC372019/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/312296/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI109367
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