Adenosine kinase inhibition promotes survival of fetal adenosine deaminase–deficient thymocytes by blocking dATP accumulation

Thymocyte development past the CD4(–)CD8(–) stage is markedly inhibited in adenosine deaminase–deficient (ADA-deficient) murine fetal thymic organ cultures (FTOCs) due to the accumulation of ADA substrates derived from thymocytes failing developmental checkpoints. Such cultures can be rescued by ove...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Van De Wiele, C. Justin, Vaughn, James G., Blackburn, Michael R., Ledent, Catherine A., Jacobson, Marlene, Jiang, Hong, Thompson, Linda F.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2002
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151094/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12163459/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI15683
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