Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling
Adenosine deaminase (ADA) deficiency in humans results in a severe combined immunodeficiency (SCID). This immunodeficiency is associated with severe disturbances in purine metabolism that are thought to mediate lymphotoxicity. The recent generation of ADA-deficient (ADA(–/–)) mice has enabled the in...
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| Published in: | J Clin Invest |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
American Society for Clinical Investigation
2001
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209335/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11435465/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10360 |
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