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Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

Adenosine deaminase (ADA) deficiency in humans results in a severe combined immunodeficiency (SCID). This immunodeficiency is associated with severe disturbances in purine metabolism that are thought to mediate lymphotoxicity. The recent generation of ADA-deficient (ADA(–/–)) mice has enabled the in...

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Udgivet i:J Clin Invest
Principais autores: Apasov, Sergey G., Blackburn, Michael R., Kellems, Rodney E., Smith, Patrick T., Sitkovsky, Michail V.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2001
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Article
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209335/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11435465/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10360
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