Adenosine deaminase deficiency increases thymic apoptosis and causes defective T cell receptor signaling

Adenosine deaminase (ADA) deficiency in humans results in a severe combined immunodeficiency (SCID). This immunodeficiency is associated with severe disturbances in purine metabolism that are thought to mediate lymphotoxicity. The recent generation of ADA-deficient (ADA(–/–)) mice has enabled the in...

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Detalhes bibliográficos

Publicado no:	J Clin Invest
Principais autores:	Apasov, Sergey G., Blackburn, Michael R., Kellems, Rodney E., Smith, Patrick T., Sitkovsky, Michail V.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Clinical Investigation 2001
Assuntos:	Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC209335/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11435465/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI10360
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