Adenosine kinase inhibition promotes survival of fetal adenosine deaminase–deficient thymocytes by blocking dATP accumulation
Thymocyte development past the CD4(–)CD8(–) stage is markedly inhibited in adenosine deaminase–deficient (ADA-deficient) murine fetal thymic organ cultures (FTOCs) due to the accumulation of ADA substrates derived from thymocytes failing developmental checkpoints. Such cultures can be rescued by ove...
Kaydedildi:
| Yayımlandı: | J Clin Invest |
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| Asıl Yazarlar: | , , , , , , |
| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
American Society for Clinical Investigation
2002
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC151094/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/12163459/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI15683 |
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