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Benzimidazole-2-one: A Novel Anchoring Principle For Antagonizing p53-Mdm2
Herein we propose the benzimidazole-2-one substructure as a suitable tryptophan mimic and thus a reasonable starting point for the design of p53 Mdm2 antagonists. We devise a short multicomponent reaction route to hitherto unknown 2-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)acetamides by reacting...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3716288/ https://ncbi.nlm.nih.gov/pubmed/22789708 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2012.06.020 |
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