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Conformational switching of the 26S proteasome enables substrate degradation
The 26S proteasome is the major eukaryotic ATP-dependent protease, responsible for regulating the proteome through degradation of ubiquitin-tagged substrates. Its regulatory particle, containing the heterohexameric AAA+ ATPase motor and the essential deubiquitinase Rpn11, recognizes substrates, remo...
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| 主要な著者: | , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712289/ https://ncbi.nlm.nih.gov/pubmed/23770819 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.2616 |
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