Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation

The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasome’s regulatory particle, consisting of lid and base subcomplexes, undergoes major confo...

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Detalles Bibliográficos
Publicado en:eLife
Autores principales: Greene, Eric R, Goodall, Ellen A, de la Peña, Andres H, Matyskiela, Mary E, Lander, Gabriel C, Martin, Andreas
Formato: Artigo
Lenguaje:Inglês
Publicado: eLife Sciences Publications, Ltd 2019
Materias:
Biochemistry and Chemical Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6910829/
https://ncbi.nlm.nih.gov/pubmed/31778111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49806
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