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Specific lid-base contacts in the 26s proteasome control the conformational switching required for substrate degradation
The 26S proteasome is essential for proteostasis and the regulation of vital processes through ATP-dependent degradation of ubiquitinated substrates. To accomplish the multi-step degradation process, the proteasome’s regulatory particle, consisting of lid and base subcomplexes, undergoes major confo...
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| Опубликовано в: : | eLife |
|---|---|
| Главные авторы: | , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
eLife Sciences Publications, Ltd
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6910829/ https://ncbi.nlm.nih.gov/pubmed/31778111 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.49806 |
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