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Diabetes Mellitus due to the Toxic Misfolding of Proinsulin Variants
Dominant mutations in the human insulin gene can lead to pancreatic β-cell dysfunction and diabetes mellitus due to toxic folding of a mutant proinsulin. Analogous to a classical mouse model (the Akita mouse), this monogenic syndrome highlights the susceptibility of human β-cells to endoreticular st...
Kaydedildi:
| Yazar: | |
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| Materyal Türü: | Artigo |
| Dil: | Inglês |
| Baskı/Yayın Bilgisi: |
2013
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| Konular: | |
| Online Erişim: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711883/ https://ncbi.nlm.nih.gov/pubmed/23669362 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2013.04.044 |
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