The Brn-2 Transcription Factor Links Activated BRAF to Melanoma Proliferation

Malignant melanoma, an aggressive and increasingly common cancer, is characterized by a strikingly high rate (70%) of mutations in BRAF, a key component of the mitogen-activated protein (MAP) kinase signaling pathway. How signaling events downstream from BRAF affect the underlying program of gene ex...

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Autors principals: Goodall, Jane, Wellbrock, Claudia, Dexter, Timothy J., Roberts, Karen, Marais, Richard, Goding, Colin R.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
Matèries:
Transcriptional Regulation
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC371133/
https://ncbi.nlm.nih.gov/pubmed/15024080
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.7.2923-2931.2004
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