Reduced caveolin-1 promotes hyper-inflammation due to abnormal heme oxygenase-1 localizationin LPS challenged macrophages with dysfunctional CFTR

We have previously reported that TLR4 signaling is increased in lipopolysaccharide (LPS) -stimulated Cystic Fibrosis (CF) macrophages (MΦs), contributing to the robust production of pro-inflammatory cytokines. The heme oxygenase (HO-1)/carbon monoxide (CO) pathway modulates cellular redox status, in...

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Hlavní autoři: Zhang, Ping-Xia, Murray, Thomas S., Villella, Valeria Rachela, Ferrari, Eleonora, Esposito, Speranza, D'Souza, Anthony, Raia, Valeria, Maiuri, Luigi, Krause, Diane S., Egan, Marie E., Bruscia, Emanuela M.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711148/
https://ncbi.nlm.nih.gov/pubmed/23606537
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1201607
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