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Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics()

Enediyne natural product biosynthesis is characterized by a convergence of multiple pathways, generating unique peripheral moieties that are appended onto the distinctive enediyne core. Kedarcidin (KED) possesses two unique peripheral moieties, a (R)-2-aza-3-chloro-β-tyrosine and an iso-propoxy-bear...

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Bibliografske podrobnosti
Main Authors: Lohman, Jeremy R., Huang, Sheng-Xiong, Horsman, Geoffrey P., Dilfer, Paul E., Huang, Tingting, Chen, Yihua, Wendt-Pienkowski, Evelyn, Shen, Ben
Format: Artigo
Jezik:Inglês
Izdano: 2013
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711097/
https://ncbi.nlm.nih.gov/pubmed/23360970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3mb25523a
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