Cloning and sequencing of the kedarcidin biosynthetic gene cluster from Streptoalloteichus sp. ATCC 53650 revealing new insights into biosynthesis of the enediyne family of antitumor antibiotics()

Enediyne natural product biosynthesis is characterized by a convergence of multiple pathways, generating unique peripheral moieties that are appended onto the distinctive enediyne core. Kedarcidin (KED) possesses two unique peripheral moieties, a (R)-2-aza-3-chloro-β-tyrosine and an iso-propoxy-bear...

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Hlavní autoři: Lohman, Jeremy R., Huang, Sheng-Xiong, Horsman, Geoffrey P., Dilfer, Paul E., Huang, Tingting, Chen, Yihua, Wendt-Pienkowski, Evelyn, Shen, Ben
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711097/
https://ncbi.nlm.nih.gov/pubmed/23360970
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c3mb25523a
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