Localized Changes in the gp120 Envelope Glycoprotein Confer Resistance to Human Immunodeficiency Virus Entry Inhibitors BMS-806 and #155

BMS-806 and the related compound, #155, are novel inhibitors of human immunodeficiency virus type 1 (HIV-1) entry that bind the gp120 exterior envelope glycoprotein. BMS-806 and #155 block conformational changes in the HIV-1 envelope glycoproteins that are induced by binding to the host cell recepto...

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Detalhes bibliográficos
Main Authors: Madani, Navid, Perdigoto, Ana Luisa, Srinivasan, Kumar, Cox, Jason M., Chruma, Jason J., LaLonde, Judith, Head, Martha, Smith, Amos B., Sodroski, Joseph G.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Vaccines and Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC371073/
https://ncbi.nlm.nih.gov/pubmed/15016894
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.7.3742-3752.2004
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